The Bernstein test is a method to reproduce symptoms of heartburn. It is most often done with other tests to measure esophageal function.
Acid perfusion test
How the Test is Performed
The test is done in a gastroenterology laboratory. A nasogastric (NG) tube is passed through one side of your nose and into your esophagus. Mild hydrochloric acid will be sent down the tube, followed by salt water (saline) solution. This process may be repeated several times.
You will be asked to tell the health care team about any pain or discomfort you have during the test.
How to Prepare for the Test
You should not eat or drink anything for 8 hours before the test.
How the Test will Feel
You may have a gagging feeling and some discomfort when the tube is put in place. The acid may cause symptoms of heartburn. Your throat may be sore after the test.
Why the Test is Performed
The test tries to reproduce symptoms of gastroesophageal reflux (stomach acids coming back up into the esophagus). It is done to see if you have the condition.
The test results will be negative.
What Abnormal Results Mean
A positive test hows that your symptoms are caused by esophageal reflux of acid from the stomach.
There is a risk of gagging or vomiting.
Fass R, Achem SR Noncardiac chest pain: diagnostic evaluation. Dis Esophagus. 2012 Feb;25(2):89-101. PMID: 21777340 www.ncbi.nlm.nih.gov/pubmed/21777340.
Kahrilas PJ, Pandolfino JE. Esophageal neuromuscular function and motility disorders. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 42.
Reviewed By:Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-Torresdale Hospital, Aria Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency
or for the diagnosis or treatment of any medical condition. A licensed medical professional
should be consulted for diagnosis and treatment of any and all medical conditions. Call 911
for all medical emergencies. Links to other sites are provided for information only -- they
do not constitute endorsements of those other sites. © 1997-A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
The Agency for Health Care Administration (Agency) and this website do not claim the information on, or referred to by, this site is error free. This site may include links to websites of other government agencies or private groups. Our Agency and this website do not control such sites and are not responsible for their content. Reference to or links to any other group, product, service, or information does not mean our Agency or this website approves of that group, product, service, or information.
Additionally, while health information provided through this website may be a valuable resource for the public, it is not designed to offer medical advice. Talk with your doctor about medical care questions you may have.