Amitriptyline and perphenazine overdose
Amitriptyline and perphenazine is a combination drug. It is sometimes prescribed for people with depression, agitation, or anxiety.
Amitriptyline and perphenazine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.
This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222.
Etrafon overdose; Triavil overdose; Triptazine overdose
Amitriptyline and perphenazine can be very harmful in large amounts.
Medicines with these brand names contain amitriptyline and perphenazine:
Other medicines may also contain amitriptyline and perphenazine.
Below are symptoms of an amitriptyline and perphenazine overdose in different parts of the body.
AIRWAYS AND LUNGS
BLADDER AND KIDNEYS
EYES, EARS, NOSE, THROAT, AND MOUTH
HEART AND BLOOD
MUSCLES AND JOINTS
- Change in menstrual patterns
STOMACH AND INTESTINES
Before Calling Emergency
Have this information ready:
- Person's age, weight, and condition
- Name of the product (ingredients and strength, if known)
- Time it was swallowed
- Amount swallowed
- If the medicine was prescribed for the person
The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.
This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.
What to Expect at the Emergency Room
Take the container to the hospital with you, if possible.
The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated.
The person may receive:
- Activated charcoal
- Blood and urine tests
- Breathing support, including a tube through the mouth into the lungs, and breathing machine (ventilator)
- Chest x-ray
- EKG (electrocardiogram, or heart tracing)
- Fluids through a vein (by IV)
- Medicines to treat symptoms (including one to reverse the effects of the poison)
- Tube through the mouth into the stomach to empty the stomach (gastric lavage)
An overdose of amitriptyline and perphenazine can be very serious.
People who overdose on this drug are almost always admitted to the hospital.
How well someone does depends on how much of the drug they swallowed and how quickly they receive treatment. The faster they get medical help, the better the chance of recovery. Complications such as pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability. Death can occur.
Brush DE, Aaron CK. Tricyclic and other cyclic antidepressants. In: Shannon MW, Borron SW, Burns MJ, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. 4th ed. Philadelphia, PA: Elsevier Saunders; 2007:chap 27.
Huffman JC, Beach SR, Stern TA. Side effects of psychotropic medications. In: Stern TA, Fava M, Wilens TE, Rosenbaum JF, eds. Massachusetts General Hospital Psychopharmacology and Neurotherapeutics. Philadelphia, PA: Elsevier; 2016:chap 12.
Velez LI, Feng S-Y. Anticholinergics. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Mosby; 2014:chap 150.
Reviewed By:Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency
or for the diagnosis or treatment of any medical condition. A licensed medical professional
should be consulted for diagnosis and treatment of any and all medical conditions. Call 911
for all medical emergencies. Links to other sites are provided for information only -- they
do not constitute endorsements of those other sites. © 1997-A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
The Agency for Health Care Administration (Agency) and this website do not claim the information on, or referred to by, this site is error free. This site may include links to websites of other government agencies or private groups. Our Agency and this website do not control such sites and are not responsible for their content. Reference to or links to any other group, product, service, or information does not mean our Agency or this website approves of that group, product, service, or information.
Additionally, while health information provided through this website may be a valuable resource for the public, it is not designed to offer medical advice. Talk with your doctor about medical care questions you may have.