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Antidiarrheal drug overdose


Antidiarrheal drugs are used to treat loose, watery, and frequent stools. This article discusses overdose of antidiarrheal drugs containing diphenoxylate or atropine. Diphenoxylate is a weak opioid, a class of drugs that includes morphine and other narcotics. Use of prescription opioids for nonmedical reasons is a growing problem among adults and teens in the United States.

This article is for information only. DO NOT use it to treat or manage an overdose of antidiarrheal medicine. If you or someone you are with overdoses, call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222.

Poisonous Ingredient

The ingredients include:

  • Diphenoxylate
  • Atropine

Where Found

These substances are found in these medicines:

  • Diphenatol
  • Lofene
  • Logen
  • Lomanate
  • Lomotil
  • Lonox
  • Lo-Trol
  • Nor-Mil

Other medicines may also contain these substances.


Someone who has overdosed on this medicine may have some of these symptoms:

Note: Symptoms may take up to 12 hours to appear.

Home Care

Seek medical help right away. DO NOT make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

  • Person's age, weight, and condition
  • Name of the product (ingredients and strengths if known)
  • Time it was swallowed
  • Amount swallowed

Poison Control

The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

What to Expect at the Emergency Room

Take the prescription bottle with you to the hospital, if possible.

The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated. The person may receive:

  • Activated charcoal
  • Breathing support, including oxygen and a tube through the mouth into the lungs
  • Chest x-ray
  • EKG (electrocardiogram, or heart tracing)
  • Intravenous fluids (given through a vein)
  • Laxative
  • Narcotic-counteracting drug (antagonist), approximately every 30 minutes
  • Tube through the nose into the stomach to empty the stomach (gastric lavage)

Outlook (Prognosis)

Most people will recover with treatment and are monitored for 24 hours. However, deaths may occur in young children. Children under age 6 should be admitted to the hospital and closely watched for 24 hours because signs of lung problems may be delayed and severe.

Keep all medicines in child-proof containers and out of reach of children. Read all medicine labels and take only medicines that have been prescribed for you.


Bardsley CH. Opioids. In: Marx JA, Hockberger RS, Walls RM, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 162.

Doyon S. Opioids. In: Tintinalli JE, Kelen GD, Stapczynski JS, Ma OJ, Cline DM, eds. Emergency Medicine: A Comprehensive Study Guide. 7th ed. New York, NY: McGraw-Hill; 2015:chap 180.

Lank PM, Kusin S. Ethanol and opioid intoxication and withdrawal. In: Adams JG, ed. Emergency Medicine. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 154.

Review Date:7/6/2015
Reviewed By:Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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Additionally, while health information provided through this website may be a valuable resource for the public, it is not designed to offer medical advice. Talk with your doctor about medical care questions you may have.

Outcome Data

No data available for this condition/procedure.

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