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Ganglioneuroma

Definition

Ganglioneuroma is a tumor of the peripheral nervous system.

Causes

Ganglioneuromas are rare tumors that most often start in autonomic nerve cells, which may be in any part of the body. The tumors are usually noncancerous (benign).

Ganglioneuromas usually occur in people ages 10 to 40. They grow slowly, and may release certain chemicals or hormones.

There are no known risk factors. However, the tumors may be associated with some genetic problems, such as neurofibromatosis type 1.

Symptoms

A ganglioneuroma usually causes no symptoms. The tumor is only discovered when a person is examined or treated for another condition.

Symptoms depend on the location of the tumor and the type of chemicals it releases.

If the tumor is in the chest area (mediastinum), symptoms may include:

  • Breathing difficulty
  • Chest pain
  • Compression of the windpipe (trachea)

If the tumor is lower down in the abdomen in the area called the retroperitoneal space, symptoms may include:

  • Abdominal pain
  • Bloating

If the tumor is near the spinal cord, it may cause:

  • Compression of the spinal cord, which leads to pain and loss of strength or feeling in the legs, arms, or both
  • Spine deformity

These tumors may produce certain hormones, which can cause the following symptoms:

  • Diarrhea
  • Enlarged clitoris (women)
  • High blood pressure
  • Increased body hair
  • Sweating

Exams and tests

The best tests to identify a ganglioneuroma are:

  • CT scan of the chest, abdomen, and pelvis
  • MRI scan of the chest and abdomen
  • Ultrasound of the abdomen or pelvis

Blood and urine tests may be done to determine if the tumor is producing hormones or other chemicals.

A biopsy or complete removal of the tumor may be needed to confirm the diagnosis.

Treatment

Treatment involves surgery to remove the tumor (if it is causing symptoms).

Outlook (Prognosis)

Most ganglioneuromas are noncancerous. The expected outcome is usually good.

A ganglioneuroma may become cancerous and spread to other areas. Or, it may come back after it is removed.

Possible Complications

If the tumor has been present for a long time and has pressed on the spinal cord or caused other symptoms, surgery to remove the tumor may not reverse the damage.

Compression of the spinal cord may result in loss of movement (paralysis), especially if the cause is not detected promptly.

Surgery to remove the tumor may also lead to complications in some cases. In rare cases, problems due to compression may occur even after the tumor is removed.

When to Contact a Medical Professional

Call your health care provider if you or your child has symptoms that may be caused by this type of tumor.

References

McCool FD. Diseases of the diaphragm, chest wall, pleura, and mediastinum. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 99.

Review Date:9/3/2014
Reviewed By:Joseph V. Campellone, MD, Department of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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