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Hemoglobin C disease

Definition

Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.

Alternative Names

Clinical hemoglobin C

Causes

Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin.

The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.

Symptoms

Most people do not have symptoms. In some cases, jaundice may occur. Some people may develop gallstones that need to be treated.

Exams and Tests

A physical exam may show an enlarged spleen.

Tests that may be done include:

Treatment

In most cases, no treatment is needed. Folic acid supplements may help your body produce normal red blood cells and improve the symptoms of the anemia.

Outlook (Prognosis)

People with hemoglobin C disease can expect to lead a normal life.

Possible Complications

Complications may include:

  • Anemia
  • Ggallbladder disease
  • Enlargement of the spleen

When to Contact a Medical Professional

Call your health care provider if you have symptoms of hemoglobin C disease.

Prevention

You may want to seek genetic counseling if you are at high risk for the condition and are considering having a baby.

References

DeBaun MR, Frei-Jones MJ, Vichinsky. Hemoglobinopathies. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 462.

Steinberg MH. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 163.

Review Date:2/1/2016
Reviewed By:Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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Outcome Data

No data available for this condition/procedure.

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Anemia

Gallstones *

Hemoglobinopathy


* Has Related Health Outcome Information

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