Main AHCA Website

AHCA’s main website for information on Medicaid, Health Quality Assurance and the Florida Center for Health Information and Transparency.

Go >

Florida Health Information Network

This website provides information and resources relating to AHCA’s initiatives for Health Information Technology and Health Information Exchange.

Go >


FloridaHealthFinder.gov

Provides health education and information to compare and locate health care providers in Florida to make well-informed health care decisions.

Go >
AHCA Network of Websites

Health Education


Health Encyclopedia

Search the Health Encyclopedia

Factor VII deficiency

Definition

Factor VII (seven) deficiency is a disorder caused by a lack of a protein called factor VII in the blood. It leads to problems with blood clotting (coagulation).

Alternative Names

Extrinsic factor deficiency; Serum prothrombin conversion accelerator deficiency

Causes

When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.

Factor VII is one such coagulation factor. Factor VII deficiency runs in families (inherited) and is very rare. Both parents must have the gene to pass the disorder on to their children. A family history of a bleeding disorder can be a risk factor.

Factor VII deficiency can also be due to another condition or use of certain medicines. This is called acquired factor VII deficiency. It can be caused by:

  • Low vitamin K (some babies are born with vitamin K deficiency)
  • Severe liver disease
  • Use of medicines that prevent clotting (anticoagulants such as warfarin)

Symptoms

Symptoms may include any of the following:

  • Bleeding from mucus membranes
  • Bleeding into joints
  • Bleeding into muscles
  • Bruising easily
  • Heavy menstrual bleeding
  • Nosebleeds that do not stop easily
  • Umbilical cord bleeding after birth

Exams and Tests

Tests that may be done include:

Treatment

Bleeding can be controlled by getting intravenous (IV) infusions of normal plasma, concentrates of factor VII, or genetically produced (recombinant) factor VII.

You will need frequent treatment during bleeding episodes because factor VII does not last for long inside the body. A form of factor VII called NovoSeven can also be used.

If you have factor VII deficiency due to a lack of vitamin K, you can take this vitamin by mouth, through injections under the skin, or through a vein (intravenously).

If you have this bleeding disorder, be sure to:

  • Tell your health care providers before you have any kind of procedure, including surgery and dental work.
  • Tell your family members because they may have the same disorder but do not know it yet.

Support Groups

Find out more about bleeding disorders through these groups:

American Society of Hematology -- www.hematology.org/Patients/Blood-Disorders.aspx

National Hemophilia Foundation: Other Factor Deficiencies -- www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies

Victory for Women with Blood Disorders --  www.hemophilia.org/Community-Resources/Women-with-Bleeding-Disorders/Victory-for-Women-with-Blood-Disorders

Outlook (Prognosis)

You can expect a good outcome with proper treatment.

Inherited factor VII deficiency is a lifelong condition.

The outlook for acquired factor II deficiency depends on the cause. If it is caused by liver disease, the outcome depends on how well your liver disease can be treated. Taking vitamin K supplements will treat vitamin K deficiency.

Possible Complications

Complications may include:

  • Excessive bleeding (hemorrhage)
  • Stroke or other nervous system problems from central nervous system bleeding
  • Joint problems in severe cases when bleeding happens often

When to Contact a Medical Professional

Get emergency treatment right away if you have severe, unexplained bleeding.

Prevention

There is no known prevention for inherited factor VII deficiency. When a lack of vitamin K is the cause, using vitamin K can help.

References

Gailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 139.

Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 177.

Review Date:1/22/2015
Reviewed By:Rita Nanda, MD, Assistant Professor of Medicine, Section of Hematology/Oncology, University of Chicago Medicine, Chicago, IL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

adam.com

The Agency for Health Care Administration (Agency) and this website do not claim the information on, or referred to by, this site is error free. This site may include links to websites of other government agencies or private groups. Our Agency and this website do not control such sites and are not responsible for their content. Reference to or links to any other group, product, service, or information does not mean our Agency or this website approves of that group, product, service, or information.

Additionally, while health information provided through this website may be a valuable resource for the public, it is not designed to offer medical advice. Talk with your doctor about medical care questions you may have.

Health
Outcome Data

No data available for this condition/procedure.

Read More

Central nervous system

Stroke *


* Has Related Health Outcome Information

Health Encyclopedia

More Features

We Appreciate Your Feedback
1. Did you find this information useful?
         Yes
         No

2. Would you recommend this website to family and friends?
         Yes
         No