Eosinophilic fasciitis is a syndrome in which muscle tissue under the skin, called fascia, becomes swollen, inflamed and thick. The hands, arms, legs, and feet can swell quickly. The condition is very rare.
The disease may look similar to scleroderma but is not related.
The cause of eosinophilic fasciitis is unknown. In people with this condition, white blood cells called eosinophils, build up in the muscles and tissues. Eosinophils are linked to allergic reactions. The syndrome is more common in people ages 30 to 60.
Symptoms may include:
Exams and Tests
Tests that may be done include:
Corticosteroids and other immune-suppressing medicines are used to relieve symptoms. These medicines are more effective when started early in the disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) may also help reduce symptoms.
In most cases, the condition goes away within 3 to 5 years. However, symptoms may last longer or come back.
Arthritis is a rare complication of eosinophilic fasciitis. Some people may develop very serious blood disorders or blood-related cancers, such as aplastic anemia or leukemia. The outlook is much worse if blood diseases occur.
When to Contact a Medical Professional
Call your health care provider if you have symptoms of this disorder.
There is no known prevention.
Lee LA, Werth VP. The Skin and Rhematic Diseases. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 43.
Reviewed By:Gordon A. Starkebaum, MD, professor of medicine, division of rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency
or for the diagnosis or treatment of any medical condition. A licensed medical professional
should be consulted for diagnosis and treatment of any and all medical conditions. Call 911
for all medical emergencies. Links to other sites are provided for information only -- they
do not constitute endorsements of those other sites. © 1997-A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
The Agency for Health Care Administration (Agency) and this website do not claim the information on, or referred to by, this site is error free. This site may include links to websites of other government agencies or private groups. Our Agency and this website do not control such sites and are not responsible for their content. Reference to or links to any other group, product, service, or information does not mean our Agency or this website approves of that group, product, service, or information.
Additionally, while health information provided through this website may be a valuable resource for the public, it is not designed to offer medical advice. Talk with your doctor about medical care questions you may have.