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Coronary artery spasm


Coronary artery spasm is a temporary, sudden narrowing of one of the coronary arteries (the arteries that supply blood to the heart). The spasm slows or stops blood flow through the artery. Part of the heart is deprived of oxygen-rich blood.

Alternative Names

Variant angina; Angina - variant; Prinzmetal's angina; Vasospastic angina


The spasm often occurs in coronary arteries that have not become hardened due to plaque buildup (atherosclerosis). However, it also can occur in arteries with plaque buildup.

These spasms are due to a squeezing of muscles in the artery wall. They most often occur in just one area of the artery. The coronary artery may appear normal during testing, but it does not function normally.

About 2% of people with angina (chest pain and pressure) have coronary artery spasm.

Coronary artery spasm occurs most commonly in people who smoke or who have high cholesterol or high blood pressure. It may occur without cause, or it may be triggered by:

  • Alcohol withdrawal
  • Emotional stress
  • Exposure to cold
  • Medicines that cause narrowing of the blood vessels (vasoconstriction)
  • Stimulant drugs, such as amphetamines and cocaine

Cocaine use and cigarette smoking can cause severe spasms of the arteries. This causes the heart to work harder. In many people, coronary artery spasm may occur without any other heart risk factors (such as smoking, diabetes, high blood pressure, and high cholesterol).


Spasm may be "silent" -- without symptoms -- or it may result in chest pain or angina. If the spasm lasts long enough, it may even cause a heart attack.

The main symptom is a type of chest pain called angina. This pain is most often felt under the chest bone (sternum) or left side of the chest. The pain is described as:

  • Constricting
  • Crushing
  • Pressure
  • Squeezing
  • Tightness

It is most often severe. The pain may spread to the neck, jaw, shoulder, or arm.

The pain of coronary artery spasm:

  • Often occurs at rest
  • May occur at the same time each day, usually between midnight and 8:00 AM
  • Lasts from 5 to 30 minutes

The person may lose consciousness.

Unlike angina that is caused by hardening of the coronary arteries, chest pain and shortness of breath due to coronary artery spasm are often not present when you walk or exercise.

Exams and Tests

Tests to diagnose coronary artery spasm may include:


The goal of treatment is to control chest pain and prevent a heart attack. A medicine called nitroglycerin can relieve an episode of pain.

Your health care provider may prescribe other medicines to prevent chest pain. You may need a type of medicine called a calcium channel blocker or a long-acting nitrate long-term. Your provider may also prescribe a short-acting nitrate to use during an episode of chest pain.

Beta-blockers are another type of medicine that is used with other coronary artery problems. However, beta-blockers may make this condition worse, and may be particularly harmful if used with cocaine.

Outlook (Prognosis)

Coronary artery spasm is a chronic condition. However, treatment most often helps control symptoms.

The disorder may be a sign that you have a high risk for heart attack or potentially deadly irregular heart rhythms (arrhythmias). The outlook is generally good if you follow your treatment recommendations and avoid certain triggers.

Possible Complications

Complications may include:

  • Abnormal heart rhythms, which may cause cardiac arrest and sudden death
  • Heart attack

When to Contact a Medical Professional

Immediately call your local emergency number (such as 911) or go to the hospital emergency room if you have a history of angina and the crushing or squeezing chest pain is not relieved by nitroglycerin. The pain may be due to a heart attack. Rest and nitroglycerin do not completely relieve the pain of a heart attack.

A heart attack is a medical emergency. If you have symptoms of a heart attack, seek medical help right away.


Take steps to reduce your risk of atherosclerosis. This includes not smoking, eating a low-fat diet, and increasing exercise.

If you have this condition, you should avoid coronary artery spasm triggers. These include exposure to cold, cocaine use, cigarette smoking, and high-stress situations.


Boden WE. Angina pectoris and stable ischemic heart disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 71.

Giugliano RP, Cannon CP, Braunwald E. Non-ST elevation acute coronary syndromes. In: Mann DL, Zipes DP, Libby P, et al, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 53.

Stern S, Bayes de Luna A. Coronary artery spasm: a 2009 update. Circulation. 2009 May 12;119(18):2531-4. PMID: 19433770

Review Date:4/20/2015
Reviewed By:Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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