Health Encyclopedia

Leucine aminopeptidase - serum

Definition

Leucine aminopeptidase is a protein, called an enzyme, that is normally found in liver cells.

Serum leucine aminopeptidase is a test that measures how much of this protein is in your blood.

Your urine can also be checked for this protein. See: Leucine aminopeptidase - urine

Alternative Names

Serum leucine aminopeptidase

How the test is performed

Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.

Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.

Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

How to prepare for the test

Your health care provider may tell you to stop taking any drugs that could affect the test. Drugs that can affect the results of this test include estrogen and progesterone. Never stop taking any medicine without first talking to your doctor.

How the test will feel

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed

Your doctor may order this test to see if your liver is damaged. Leucine aminopeptidase is released into the blood when your liver cells are damaged. Drugs or infections such as hepatitis can damage liver cells.

Liver tumors may also release this protein into the bloodstream. This test may be used to look for signs of such tumors, but usually other tests are done instead.

Normal Values

Male: 80 to 200 U/mL
Female: 75 to 185 U/mL

Note: U/mL = units per milliliter

What abnormal results mean

Cholestasis
Cirrhosis
Hepatitis
Liver ischemia (blood deficiency)
Liver necrosis (tissue death)
Liver tumor

What the risks are

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

Excessive bleeding
Fainting or feeling light-headed
Hematoma (blood accumulating under the skin)
Infection (a slight risk any time the skin is broken)

References

McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. St. Louis, Mo: WB Saunders; 2006.

Review Date:5/29/2007
Reviewed By:Daniel R Alexander, MD, Department of Internal Medicine, St. Mary's Hospital, Leonardtown, MD. Review provided by VeriMed Healthcare Network.

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