Health Encyclopedia

Melanoma of the eye

Definition

Melanoma of the eye is cancer that occurs in various structures in the eye, such as the choroid, the iris, or the ciliary body. The choroid layer is the most likely location of melanoma in the eye.

Alternative Names

Malignant melanoma - choroid; Malignant melanoma - eye; Eye tumor; Ocular melanoma

Causes, incidence, and risk factors

Melanoma is a very aggressive type of cancer that can spread rapidly. It often affects the skin.

Melanoma is the most common type of eye tumor in adults. Even so, primary melanoma of the eye is rare.

The cancer may only be in the eye, or it may spread to another location in the body. There may be no early symptoms, but the tumor will eventually cause a retinal detachment and distortion of vision.

Excessive exposure to sunlight is an important risk factor. The occurrence of melanoma has greatly increased in recent decades. Fair-skinned and blue-eyed people are affected most often.

Symptoms

A red, painful eye
Small defect on the iris or conjunctiva
Iris color may change
Poor vision in one eye
Bulging eyes

In some cases, there may be no symptoms.

Signs and tests

An eye examination with an ophthalmoscope reveals a single round or oval lump (tumor) within the eye.

Tests may include:

Eye ultrasound examination
Cranial CT scan to look for spread (metastasis) to the brain
MRI of the head to look for metastasis to the brain
Skin biopsy if there is an affected area on the skin

Treatment

Small melanomas may be treated with lasers or by radiation therapy. Chemotherapy may be needed if the tumor has spread. Surgical removal of the eye may be necessary to prevent the spread of tumor to the brain or other organs.

Support Groups

For additional resources, see cancer support group.

Expectations (prognosis)

The outcome for melanoma of the eye depends upon the size of the cancer at the time of diagnosis. Between 60% and 80% of patients will survive at least 5 years from the time of diagnosis if the cancer has not spread outside the eye (metastasized).

If there has been spread outside the eye, the chance of survival is much lower.

Complications

Spread of the tumor to other areas of the body is a complication.

Calling your health care provider

Call for an appointment with your health care provider if a melanoma of the eye is suspected.

Prevention

The most important way to prevent eye melanoma is to avoid excessive exposure to sunlight, especially between 10 a.m. and 2 p.m., when the sun's rays are most intense. Wear sunglasses, and be sure they have ultraviolet protection.

Review Date:5/3/2006
Reviewed By:William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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