Health Encyclopedia

Progressive multifocal leukoencephalopathy

Definition

Progressive multifocal leukoencephalopathy (PML) is a rare disorder that damages the material (myelin) that covers and protects nerves in the white matter of the brain.

Alternative Names

PML

Causes, incidence, and risk factors

The JC virus (JCV) causes PML. This virus is found in a lot of people, but usually does not cause symptoms. However, it triggers PML in people who have poor immune function (immunocompromised).

The disease occurs in 4% of adults with AIDS.

Symptoms

Headaches
Loss of coordination, clumsiness
Loss of language ability (aphasia)
Memory loss
Vision problems
Weakness of the legs and arms that gets worse

Signs and tests

Tests may include:

Treatment

Treatment consists of antiviral drugs and other medications.

Expectations (prognosis)

PML is a very serious condition. Talk to your doctor about care decisions.

References

Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 5th ed. London: Churchill Livingstone; 2000:1856-1861.

Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:2046.

Review Date:2/13/2008
Reviewed By:Luc Jasmin, MD, PhD, Departments of Anatomy & Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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