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Hypogonadotropic hypogonadism is absent or decreased function of the male testes or the female ovaries. It is considered a form of secondary hypogonadism, which means the condition is due to a problem with the pituitary or hypothalamus gland.
See also: Hypogonadism
Gonadotropin deficiency; Secondary hypogonadism; Kallmann syndrome
Hypogonadotropic hypogonadism results from the absence of the gonadal stimulating pituitary hormones: Follicle stimulating hormone (FSH) and Luteinizing hormone (LH).
Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release other hormones, including FSH and LH. These hormones tell the female ovaries and male testes to secrete hormones that are responsible for normal sexual development in puberty. A disruption in this chain of events causes a deficiency of the sex hormones and halts normal sexual maturation.
Failure of the hypothalamus is most commonly a result of Kallmann syndrome. Kallmann syndrome is an inherited form of hypogonadotropic hypogonadism that usually includes involves a disorder with the sense of smell.
Tests that may be done include:
Treatment depends on the source of the problem but may involve:
With proper hormonal stimulation, puberty can occur and fertility may be restored.
Call your health care provider if your child does not enter puberty as expected.
Prevention depends on the cause. Genetic counseling may be appropriate for individuals with a family history of inherited disorders associated with hypogonadism. Prevention of serious head injuries reduces the risk of pituitary injury associated hypogonadotropic hypogonadism.
AACE Thyroid Task Force. AACE Hypogonadism Guidelines. Endocr Pract. 2002;8(6) 441.
Review Date:10/24/2007
Reviewed By:Robert Hurd, MD, Professor of Endocrinology, Department of Biology, Xavier University, Cincinnati, OH, and physician in the Primary Care Clinic, Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio. Review provided by VeriMed Healthcare Network.
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