Health Encyclopedia

Anaplastic thyroid cancer

Definition

Anaplastic thyroid carcinoma is an aggressive form of cancer of the thyroid gland.

Alternative Names

Anaplastic carcinoma of the thyroid

Causes, incidence, and risk factors

Anaplastic thyroid cancer grows very rapidly and is an invasive type of thyroid cancer. It occurs most often in people over age 60. The cause is unknown. Thyroid function tests are usually normal. Anaplastic cancer accounts for only about 1% of all thyroid cancers and is a very rare disease.

Symptoms

Lower neck mass, often noted to be enlarging
Hoarseness or changing voice
Cough
Coughing up blood
Difficulty swallowing
Loud breathing

Signs and tests

A physical examination may show a neck mass.

A thyroid biopsy shows anaplastic carcinoma
An isotope study of the thyroid (thyroid scan) shows this mass to be "cold", meaning it does not absorb the isotope.
A CT scan or MRI may show a tumor growing from the thyroid gland.
An examination of the airway with a fiberoptic scope (laryngoscopy) may show a paralyzed vocal cord.

Treatment

This type of cancer is treated with surgery to remove the tumor, or radiation therapy, or both. Surgery may require placement of a tube in the throat to help breathing (tracheostomy). This tumor is not responsive to radioactive iodine, which is used to treat other types of thyroid cancer. It is also usually not responsive to chemotherapy.

Support Groups

The stress of illness can often be eased by joining a support group of people sharing common experiences and problems. See cancer - support group.

Expectations (prognosis)

The prognosis of this disease is poor. Less than 5% of patients survive 5 years. Most people do not survive longer than 6 months.

Complications

Spread of tumor within the neck
Metastasis (spread) of cancer to other body tissues or organs

Calling your health care provider

Call your health care provider if there is a persistent lump or mass in the neck, hoarseness, changing voice, cough or coughing up blood.

Review Date:5/26/2006
Reviewed By:Rita Nanda, M.D., Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided byVeriMed Healthcare Network.

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