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VIPoma

Definition

VIPomas are a very rare type of cancer that grows from certain cells in the pancreas.

Alternative Names

Vasoactive intestinal peptide-producing tumor; Pancreatic endocrine tumor

Causes, incidence, and risk factors

VIPomas affect cells in the pancreas that produce a hormone called vasoactive intestinal peptide (VIP). The cancer causes symptoms by producing high levels of this hormone. The cause is not known.

VIPomas are usually diagnosed in adulthood, most commonly at age 50. Women are more likely to be affected than men.

Symptoms

• Watery diarrhea (often massive amounts)
• Hypokalemia (low blood potassium), which can cause leg cramps
• Low acid in the stomach (achlorhydria)
• Nausea
• Dehydration
• Abdominal pain and cramping
• Weight loss
• Facial flushing or redness

Signs and tests

• High level of VIP (vasoactive intestinal peptide) in the blood
• High volume of diarrhea (continues despite fasting)

Fasting is one way to test for VIPoma.

The physician may also request that the stool be collected and analyzed to determine electrolyte content.

A CT scan or MRI may be ordered to determine the location of the tumor.

Treatment

The first goal of treatment is to correct dehydration. Intravenous (IV) fluids are often required to replace fluids lost in diarrhea.

The next goal is to slow the diarrhea. Some medications can help control the diarrhea, such as octreotide, which is a hormone.

The best chance for cure is surgery to remove the tumor. If the tumor has not metastasized (spread to other organs), surgery can often cure it.

Expectations (prognosis)

Surgery can usually cure VIPomas, but about one-third to one-half of patients will have tumors that have spread by the time of diagnosis and are thus incurable.

Complications

• Metastasis
• Dehydration
• Cardiac arrest from electrolyte imbalances

Calling your health care provider

If you have watery diarrhea for more than 2-3 days, you should call your doctor.

Review Date:9/11/2006
Reviewed By:Rita Nanda, M.D., Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.

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