Health Encyclopedia

Cor pulmonale

Definition

Cor pulmonale is failure of the right side of the heart caused by prolonged high blood pressure in the pulmonary artery and right ventricle of the heart.

Alternative Names

Right-sided heart failure - cor pulmonale

Causes, incidence, and risk factors

Normally, the left side of the heart produces a higher blood pressure in order to pump blood to the body. The right side pumps blood through the lungs under much lower pressure.

Any condition that leads to prolonged high blood pressure in the arteries or veins of the lungs (called pulmonary hypertension) puts a strain on the right side of the heart. When this right ventricle fails or is unable to properly pump against these abnormally high pressures, this is called cor pulmonale.

Almost any chronic lung disease or condition causing prolonged low blood oxygen can lead to cor pulmonale. A few of these causes include:

Chronic obstructive pulmonary disease (COPD)
Obstructive sleep apnea
Central sleep apnea
Mountain sickness
Cystic fibrosis
Primary pulmonary hypertension
Pneumoconiosis
Kyphoscoliosis
Interstitial lung disease
Chronic thromboembolic pulmonary disease
Pulmonary vascular disease
Pulmonary hypertension

Symptoms

Shortness of breath
Symptoms of underlying disorders (wheezing, coughing)
Swelling of the feet or ankles
Exercise intolerance
Chest discomfort

Signs and tests

Bluish color to the skin (cyanosis)
Distension of the neck veins indicating high right-heart pressures
Abnormal fluid collection in the abdomen, enlargement of the liver
Swelling of the ankles
Abnormal heart sounds

The following tests may help diagnose cor pulmonale:

Echocardiogram (heart ultrasound)
Chest x-ray
CAT scan of the chest
Pulmonary function tests
Swan-Ganz catheterization
V/Q scan
Measurement of blood oxygen by arterial blood gas (ABG)
Lung biopsy (rarely performed)
Blood antibody tests
Blood test for brain natriuretic peptide (BNP)

Treatment

Treatment is directed at the underlying illness. Supplemental oxygen may be prescribed to increase the level of oxygen in the blood.

There are many medicines available to treat cor pulmonale. Calcium channel blockers are often used to treat early cases. Prostacyclin may be given through injection or inhalation. Bosentan or sildenafil may also be given by mouth.

Blood thinning (anticoagulant) medications may also be prescribed. Surgery may be needed to reverse heart defects that cause the condition. In very advanced cases, heart and lung transplantation may be advised.

Expectations (prognosis)

The outcome depends on the underlying cause. Giving oxygen often results in improved symptoms, more stamina, and longer survival.

Treatment of primary pulmonary hypertension often leads to more stamina and longer life. In some cases, lung transplant or heart-lung transplant can result in longer survival.

Complications

Progressive pulmonary hypertension and cor pulmonale may lead to severe fluid retention, life-threatening shortness of breath, shock, and death.

Calling your health care provider

Call your health care provider if you experience shortness of breath or chest pain.

Prevention

Avoiding behaviors that lead to chronic lung disease (especially cigarette smoking) may prevent the eventual development of cor pulmonale. Careful evaluation of childhood heart murmurs may prevent cor pulmonale caused by certain heart defects.

Review Date:11/13/2006
Reviewed By:David A. Kaufman, M.D., Assistant Professor, Division of Pulmonary, Critical Care & Sleep Medicine, Mount Sinai School of Medicine, New York, NY. Review provided by VeriMed Healthcare Network.

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